It absolutely depends on genre. For most Japanese-style RPGs (Final Fantasy, SMT, etc.) I will play on normal mode. For anything action, I want easy at the most. For something with a shootybang element, I want the easiest it will give me and ideally a story-only mode. I generally don't turn it up beyond that (SMT in particular it's a pride thing to play on Normal but I don't hate myself and my free time enough to try Hard).